Nucleoside transport in Walker 256 rat carcinosarcoma and S49 mouse lymphoma cells. Differences in sensitivity to nitrobenzylthioinosine and thiol reagents
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Nucleoside transport in Walker 256 rat carcinosarcoma and S49 mouse lymphoma cells. Differences in sensitivity to nitrobenzylthioinosine and thiol reagents.
The characteristics of nucleoside transport were examined in Walker 256 rat carcinosarcoma and S49 mouse lymphoma cells. In Walker 256 cells the initial rates of uridine, thymidine and adenosine uptake were insensitive to the nucleoside transport inhibitor nitrobenzylthioinosine (NBMPR) (1 microM), but were partially inhibited by dipyridamole (10 microM), another inhibitor of nucleoside transpo...
متن کاملNitrogen Mustard Sensitivity and Choline Transport in Walker 256 Carcinosarcoma Cells in Vitro1
supplemented with 10% horse serum. The cells grew ex ponentially with a doubling time of 16 to 17 hours, had a cell volume (mean ±S.E.) of 2313 ±89 cu /tm, and were cloned in soft agar with a cloning efficiency of 68.7 ±6.3%. Sensitivity to the alkylating agent nitrogen mustard (HN2) was comparable to that observed previously with LSI78Y murine lymphoblasts; the D0 (the dose of drug reducing...
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supplemented with 10% horse serum. The cells grew ex ponentially with a doubling time of 16 to 17 hours, had a cell volume (mean ±S.E.) of 2313 ±89 cu /tm, and were cloned in soft agar with a cloning efficiency of 68.7 ±6.3%. Sensitivity to the alkylating agent nitrogen mustard (HN2) was comparable to that observed previously with LSI78Y murine lymphoblasts; the D0 (the dose of drug reducing...
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The complete nucleotide sequences of both rat liver and Walker 256 mammary carcinosarcoma tRNAAsn reveal that they are identical except for the nucleotide present in the wobble position of the anticodon loop. The rat liver tRNAAsn contains the Q nucleoside, whereas the tumour tRNAAsn contains an unmodified guanosine. The tRNAs from both tissues also show significant quantitative differences in ...
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The endogenous electric field (EF) may provide an important signal for directional cell migration during wound healing, embryonic development and cancer metastasis but the mechanism of cell electrotaxis is poorly understood. Additionally, there is no research addressing the question on the difference in electrotactic motility of cells representing various strategies of cell movement-specificall...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1985
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2320681